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De helpdesk bevat meer dan 1500 vragen en antwoorden over diverse galenische topics, allemaal aangeleverd door Prof. R. Kinget.
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What can be used as an alternative for sodium metabisulfite to prevent brown discoloration in a LAT-gel formulation due to its current backorder, given the following components: 0.667 g tetracaine HCl, 0.1 g sodium metabisulfite, 3.067 g lidocaine HCl, 0.243 g adrenaline bitartrate, one 20 ml miniplasco of water for injection, and four 30 ml tubes of Xylocaine 2% gel?
Regarding the preparation of an improved water paste according to Prof. Kinget, how should one begin the process, specifically concerning whether the Veegum dispersion should be made separately with warm water or if the 25g of water from the recipe can be used, and will the Na-CMC swell within the Veegum dispersion?
Regarding the preparation of a 10mg/ml omeprazole syrup for pediatric use in a pH 8 excipient, while following the TMF method for a 0.2mg/ml syrup, does using 1g of omeprazole per 100ml require a different amount of NaHCO3; does the TMF requirement for homogenization imply the use of a rotor-stator mixer; is it permissible to add sodium saccharinate to mask the extremely bitter taste; and could there be issues with the resuspendability and pH of this 1% suspension?
Could you provide advice on preparing a sterile eye ointment containing 5% sodium chloride, 15% water, 15% lanolin, and 65% white petrolatum, specifically regarding whether we should prepare this ourselves or avoid it, what considerations are necessary if we use a hospital's laminar air flow cabinet, what the step-by-step procedure is, and how to sterilize the individual ingredients and logistics, given that the preparation is only difficult because it must be delivered sterile?
What is the preparation for the following formula: 60mL rose water, 54g white wax, and 183g sweet almond oil?
How can a stable formulation for oxybutynin syrup be prepared starting from Ditropan tablets?
What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?
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