I am experiencing clumping issues while preparing 20 suppositories containing 400mg paracetamol, 400mg acetylsalicyl acid, 100mg caffeine, and 20mg codeine phosphate; since the powder sticks together and does not mix well with the base, what am I doing wrong?

What is the best method to prepare 500 ml of bath oil containing 200 ml Miglyol, 50 g Eumulgin B1, 50 ml Comperlan COD, 50 ml Cetiol V, 150 ml soybean oil, and 5% urea?

Is a hidden incompatibility possible between chlorhexidine digluconate and Primojel in a "loco" preparation for Decusorb consisting of 57.69 g reverse osmosis water, 5.31 g macrogol 400, 1.48 g chlorhexidine digluconate 20% solution, and 10.77 g sodium starch glycolate (Primojel), prepared by dissolving chlorhexidine and PEG in water before stirring in Primojel with a Stephan mixer, given that a potential interaction exists between cationic chlorhexidine and anionic carboxymethyl starch, leading the APB to recommend methylcellulose while a hospital pharmacy claims the preparation is stable with chlorhexidine acting as a preservative?

How can a 10% resorcinol preparation be successfully completed when carbomer and HPC gels break upon contact with the substance, and HEC gel, a potential solution, is unavailable at the wholesaler?

We have been asked to create a cream using Aacifemine ovules because the cream is currently unavailable; is this possible?

Why does the order of addition affect the following prescription: Ventolin syrup 150ml, promethazine HCl 225mg, pseudoephedrine 450mg, distilled water 15ml, pholcodine 225mg, and 2.7g of 94 percent ethanol for a total of 150ml? Why is it important to first dissolve the promethazine and pseudoephedrine in water and add the Ventolin before adding the pholcodine in alcohol, given that adding Ventolin last results in precipitation? What is the explanation for this precipitation, could it be promethazine base, and is it necessary to add citric acid or ascorbic acid as an antioxidant to protect the promethazine?

What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?