What is the cause of the precipitate that forms at the bottom of the bottle over time in a mouthwash containing 0.04% benzocaine, 0.1% NaEDTA, 20mg sodium saccharinate, and peppermint water (3% peppermint spirit) up to 100ml?

What is the cause and how can we prevent the release of water during the preparation of a compound containing 15 mg clobetasone propionate, 3 g urea, 10 g crotamiton, and 300 mg menthol in a base of vaseline cum aqua + arlacel NF6 up to 100 g, noting that the issue does not occur when the AVA cream is replaced with cetomacrogol cream?

How can a stable suspension be obtained for a formulation containing 1g colistin sulfate, 0.8g tobramycin sulfate, 200mg Na CMC, 5ml glycerol, and purified water up to 60ml, given that colistin sulfate behaves hydrophobically and clumps in water despite being described as freely soluble, and the current method of wetting with glycerol and rubbing with Na CMC results in separation after 10 minutes and complete sedimentation after 2 hours?

What factors must be considered during the preparation of indomethacin gel 1%, given that the pH must be between 5.4 and 5.8, the viscosity will be too low due to neutralization to pH 5, and the indomethacin must be processed in its non-ionized form to ensure proper skin penetration?

Can the concentration of midazolam syrup change after three weeks, given that the pediatric department observes children sleeping longer after receiving the bottom portion of a bottle that is replaced every three weeks; specifically, could this be caused by sedimentation requiring a "shake before use" instruction, or by midazolam converting into a more potent substance when combined with Liga Cé, noting that nurses do not see visible precipitation in the formulation consisting of 30 ml midazolam (from 50 mg/10 ml Mini-Plasco's), 20 ml concentrated Liga Cé syrup, and 25 ml aqua conservans?

What is the indication for the following ointment containing 1mg/g glutamine, 0.25mg/g nicotinamide, and 0.2mg/g tryptophan in a 35g base, and which ointment base is best used?

What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?