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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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Why does a dental gel composed of 37% phosphoric acid, 0.1% sodium lauryl sulfate, 0.001% methylene blue, and aqua ad 100%, which achieves a semi-liquid consistency using 2% hypromellose, become liquid over time, and is this instability caused by the influence of the acid?
How can I prevent the liquefaction of the gel when using the new prefabricated carbomer gel in a preparation containing 500 mg sodium diclofenac and carbomer gel TMF up to 50 g, and would adding Tween 80 be an appropriate solution?
What could cause mold growth in a preparation of 2% erythromycin and 0.1% triamcinolone acetonide in 250 g of unbuffered cetomacrogol cream, given that it was initially prepared with a good result but showed mold after two weeks despite being stored under normal conditions?
Given that a patient is inquiring about a compounded vitamin B complex for preventing mosquito bites and various sources such as the national formulary, PMF, and MFS provide differing compositions and dosages—specifically for thiamine, ranging from 5 mg to 250 mg—what is the correct dosage and composition for this purpose?
What is a suitable alternative for cetyl palmitate (walschot) in a preparation for 10 suppositories containing 2% allantoin, 15% yellow petrolatum, 20% cetyl palmitate, and cocoa butter up to 100%, given that cetyl palmitate is no longer available?
What is the best way to prepare a lotion containing 1 g salicylic acid, 4 g almond oil, 100 ml denatured ethanol 96%, and water up to 200 ml, specifically regarding whether Tween should be added to keep the oil emulsified or isopropyl myristate should be added to improve the solubility of the salicylic acid, and in what quantities?
What is the recommended preparation method for suppositories containing 45 mg of methoxsalen (8-MOP) per suppository, and is it necessary to first triturate the bulky bulk product with silica before adding it to the suppository base?
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