What is the best way to prepare suppositories containing 150 mg ichthammol, 10 mg belladonna dry extract, and 1% lidocaine, to be used twice daily for 14 days?

What are some recommendations for the preparation of suppositories containing ichthammol and dry extract of horse chestnut, specifically regarding the method of mixing the ichthammol with castor oil before adding it to the molten suppository base, followed by the addition of the dry extract mixed with colloidal silicon dioxide (Aerosil)?

What is the cause of the white crystals that gradually increase in size after three days in a gel containing 15 g diprophylline, 3 g ruscus tincture, 300 mg diphenhydramine HCl, 10 mg triamcinolone, and 37,500 IU sodium heparin per 100 g, when methylcellulose gel FN VI was used as a base because carbopol gel is incompatible with diphenhydramine HCl?

To what extent can triethanolamine be replaced by trometamol in formulas that are now being excluded, particularly regarding reimbursement, such as in a preparation containing 30 g paraffin, 20 g white vaseline, 19 g almond oil, 15 g sorbitol, 3 g urea, 15 g glycerol, 3 g stearic acid, 7 g triethanolamine, 3 g cetyl alcohol, and water up to 300 g?

Is there a potential interaction between Xylocaine HCl and Na CMC in a stomatitis cocktail containing 2,400,000 UI Nystatin, 200 mg Prednisolone, 400 mg Xylocaine HCl, 2 g Na CMC, 10 ml propylene glycol, and purified water up to 500 ml, given that one is positively charged and the other is negatively charged?

In the preparation of a solution containing 4 g sodium benzoate, 80 ml codeine syrup, 100 ml raspberry syrup, and water up to 200 ml, where sodium benzoate converts to benzoic acid in the acidic environment of the raspberry syrup, is this conversion desired for its preservative properties, or is it undesirable, necessitating the replacement of raspberry syrup with simple syrup, and what is the specific function of sodium benzoate in this formulation?

Does the yellow discoloration caused by an interaction between clioquinol (Vioform) and zinc oxide (ZnO), as observed in the clioquinol water paste from the TMF, lead to a reduction in activity?