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De helpdesk bevat meer dan 1500 vragen en antwoorden over diverse galenische topics, allemaal aangeleverd door Prof. R. Kinget.
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A pharmacist often receives a prescription for 6 g sodium alginate, 150 mg sodium saccharinate, 15 ml peppermint spirit, and water up to 50 ml; although this initially forms a clear solution, it precipitates after approximately two weeks. What could best be added to this preparation to keep it stable for a longer period, given that the patient wants to prepare several batches in advance for their vacation?
Which emulsifier, not derived from palm oil or any nut oil, is suitable for incorporating water into vaseline for a 9-year-old patient who suffers from extreme allergic reactions, including respiratory distress and arrest, to these components and cannot use over-the-counter dermatological products?
Regarding the preparation of an emulsion containing 8.5 g liquid paraffin, 8.5 g peanut oil, 7 g cetostearyl alcohol, 1.7 g cetomacrogol 1000, 50 mg butylhydroxytoluene, 100 mg benzoic acid, 2.5 g Tween 80, and water up to 100 g, why does adding Tween 80 to the aqueous phase result in a preparation that is too liquid, whereas adding it to the fatty phase produces the correct consistency, and is it permissible to add the Tween 80 to the fatty phase?
How can 60 suppositories each containing 500 mg of Depakine Chrono be prepared following a palliative care prescription, considering whether such a large amount of powder can be acceptably processed into suppositories and if the controlled-release properties of the Chrono tablets will be maintained after trituration?
How can a 100 ml preparation of 4% erythromycin in a 1% hydroxypropyl methylcellulose (HPMC) solution be formulated to avoid precipitation, given that erythromycin is poorly soluble in water and a precipitate forms when the 1% HPMC solution is added to a 1:5 erythromycin-ethanol solution?
How do I prepare a 5% NaOCl solution, does NaOCl exist as a bulk product, and are there special considerations I should keep in mind?
Can the fine precipitate that forms at the top of the bottle when adding 0.9 g of propolis MT to dextromethorphan syrup (up to 200 ml) be avoided?
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