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De helpdesk bevat meer dan 1500 vragen en antwoorden over diverse galenische topics, allemaal aangeleverd door Prof. R. Kinget.
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How can the sulfur taste caused by the breakdown of carbocisteine in a syrup be prevented, given that a new syrup flavored with cinnamon syrup—similar to Muco-Rhinathiol—initially improved the taste but saw the sulfur flavor return after one week?
Given that the Therapeutic Magistral Formulary recommends a trituration for corticosteroids, but preparing such a trituration with micronized powders presents significant difficulties due to electrostatic forces, is it sufficient to simply mix them with mannitol or lactose, or can 1% talc be added as an anti-static agent to achieve a high-quality and manageable powder?
What is the formula for a generic diclofenac gel, given that a prescription has been received for it and Voltaren gel contains 1% diclofenac?
Can lactose monohydrate be used as a substitute for anhydrous lactose, which is commercially unavailable, in a preparation of ovules containing 250 mg metronidazole and 1 million UI nystatin, and what measures can be taken to prevent the ovules from breaking when removing them from the mold, given that Suppocire AS2X is used as the base, the preparation is cooled at room temperature, and the mold used has large ovules with a calibration mass of 11.7 g?
Is there an option to extend the one-month shelf life of fortified eye drops containing tobramycin 15 mg/ml and vancomycin 25-50 mg/ml, which are currently prepared in a laminar air flow (LAF) cabinet for stock at the ophthalmology department to avoid after-hours calls?
What is the best way to prepare a solution containing 0.3 g triamcinolone acetonide, 15 g liquor carbonis detergens, 15 g salicylic acid, 6 g castor oil, and 50 degree spirit up to 300 g, and what is the solubility of triamcinolone acetonide in this mixture?
What is the best way to prepare the following formula: 300 mg of trimethoprim and simple syrup up to 60 ml?
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