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De helpdesk bevat meer dan 1500 vragen en antwoorden over diverse galenische topics, allemaal aangeleverd door Prof. R. Kinget.
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How can the liposomal gel formulas for 5 g hydrocortisone and 1 g testosterone be prepared when Phospholipon 90 G is out of stock, given that both prescriptions also include 10 g propylene glycol, 10 g glycerol, 3 g TMF carbomer mixture, and water up to 100 g?
Which sterilization method can be applied in the pharmacy for a sterile oil solution consisting of 3 grams of Niaouli volatile oil and 27 grams of olive oil, given the availability of an autoclave, sterile membrane filters, and a Memmert drying oven (up to 200°C)?
What is the shelf life of a syrup containing 730 mg sodium prednisolone phosphate, 944 mg disodium phosphate dihydrate, 210 mg sodium dihydrogen phosphate dihydrate, 100 mg disodium edetate, 25.8 g liquid sorbitol, 4 drops of banana flavor, and preserved water up to 100 ml?
Can ethanol be present in a metronidazole syrup, given that flavorings like orange peel tincture almost all contain ethanol, and is there a disulfiram-like effect present?
Can propylene glycol be replaced by 10 ml of glycerol as a solvent in a mouthwash for a pregnant patient—specifically for a preparation containing nystatin (24 ml specialty), prednisolone (200 mg), lidocaine HCl (400 mg), sodium carmellose (2 g), propylene glycol (10 ml), peppermint spirit (2%), and distilled water up to 500 ml—given that nystatin is not absorbed orally, prednisolone and lidocaine HCl are not teratogenic, and while the mouthwash is not swallowed, propylene glycol is potentially toxic and literature lacks data regarding glycerol use in pregnancy; additionally, would this substitution significantly impact solubility, preparation method, or stability, and can the same volume be used?
How should Chloorhexidine 0.1% eye drops FNA be prepared after being requested by an ophthalmologist?
What is the cause of the thick, soap-like foam layer forming on the surface during the preparation of a trimethoprim suspension containing 1 g trimethoprim, 7 g glycerol, 0.25% carbomer TMF, 30 ml sorbitol, and q.s. sodium saccharin and banana aroma, given that it is not flotation?
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