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De helpdesk bevat meer dan 1500 vragen en antwoorden over diverse galenische topics, allemaal aangeleverd door Prof. R. Kinget.
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Are miconazole nitrate 2% and salicylic acid 2% compatible when prepared in a buffered cetomacrogol cream, considering the potential theoretical interaction between the miconazole cation and salicylate anion, and what effects can be expected regarding stability or enhanced penetration, given that the branded Daktarin cream uses benzoic acid as a preservative?
Why does a flocculent precipitate form when neomycin sulfate is added to Beconase Aqua diluted with water, and how can the formula—consisting of 10 mL Beconase Aqua, 0.2 g glycerin, 0.2 g propylene glycol, 4.5 g dextrose, 100 mg neomycin sulfate, 5 KE bacitracin, and distilled water up to 100 mL—be adjusted to prevent this?
What is the difference between Lanette cream and Lanette wax cream, and are these two terms used interchangeably?
What are the recommended concentrations for acetic acid and boric acid in a magistral alternative to Otic Domeboro ear drops for divers, given that the identified composition includes 2% acetic acid, water, aluminum acetate, sodium acetate, and boric acid, and considering the proposal to dissolve acetic acid and boric acid in a 1/10 Burow's solution?
Given that a young patient refuses to take Keppra oral solution, and the physician has inquired about the possibility of compounding 600 mg capsules to be opened and mixed with food, considering levetiracetam's unpleasant taste, is there a specific syrup that could be used to dissolve or suspend levetiracetam from tablets to provide a more palatable alternative?
What is the appropriate preparation method for a nasal ointment containing 150 mg eucalyptol, 300 mg borax, 300 mg L-ephedrine HCl, a 1 ml ampoule of 0.1% adrenaline bitartrate, 20 g white vaseline, and 10 g sweet almond oil to prevent the formation of a flaky precipitate?
Is lidocaine compatible with isosorbide dinitrate, specifically in a formula containing 500 mg of isosorbide dinitrate and 50 g of 2% Xylocaine, and can this preparation be incorporated into a TMF ointment base?
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