How can I prepare a Tildiem 2% gel in a NaCMC gel base up to 100 g, and which specialty product is best to use to process 2 g of active substance, given that the raw material diltiazem HCl is unavailable at the wholesaler?

What is the solution for preparing glycerol ointment when rice starch is used instead of wheat starch, which is unavailable at the wholesaler, and 6 g of salicylic acid is dissolved in the heated glycerol, but the preparation—following the Belgian Pharmacopoeia—remains liquid and milky white instead of forming a thick, translucent mass upon stirring and cooling?

What is the recommended thickening agent for a suspension containing 20 g of kaolin and 0.5 g of pectin, similar to the former Kaopectate, and what are the suggestions for flavoring and the preparation method?

How can a glossy o/w cream be formulated using 14.5% w/w white soft paraffin, 12.6% w/w light liquid paraffin, and 1% w/w hypoallergenic anhydrous lanolin (Medilan) to match E45 Cream, given that previous attempts with 3% Tween 80, 3% Lanette SX, and a combination of 1% white wax with 2% Tween 80 resulted in either breaking, excessive liquidity, or a white residue?

What is the cause for a preparation containing 15 mg tretinoin, 3.6 g denatured alcohol, 12 mg butylhydroxytoluene, 4% hydroquinone, and 0.5% hydrocortisone acetate in cetomacrogol cream up to 300 g having a shelf life of only about 14 days, and how can the formula be improved?

Given that Orthogynest Depot has been discontinued, what base should be used for a "loco" preparation, such as a mixture of PEG 4000 and PEG 1500/300, and in what ratio; how can a depot effect be achieved, perhaps by adding 2% Aerosil; is an additional preservative required; and can a 2 g suppository mold be used instead of an ovule mold, as it is the first time in 15 years of pharmaceutical practice that these ovules must be prepared?

What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?