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La mesa de ayuda de formulación contiene más de 1500 preguntas y respuestas sobre diversos temas galénicos, todas proporcionadas por el Prof. R. Kinget.
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How much glucose or glycerol must be added to obtain isotonic Argyrol 0.5% nasal drops?
Is the reasoning correct that betamethasone dipropionate and valerate esters migrate to the interface in two-phase systems (o/w and w/o emulsions), given that betamethasone dipropionate is nearly insoluble in water (0.7 mg/L) but soluble in lipophilic solvents, and could this positioning explain both the rearrangement of betamethasone-17-valerate to the less active 21-valerate at pH > 6 and ester hydrolysis at pH > 7, despite the aqueous phase typically being buffered to pH 4-5 in most corticosteroid creams for stability?
What is the formulation for an oral Lugol's solution used for thyroid blockade during a nuclear medicine examination?
Does a specialty mouthwash containing hydrogen peroxide exist?
What is the ideal preparation method for a solution containing 4 g minoxidil, 60 mg betamethasone valerate, 20 g propylene glycol, 30 g alcohol 60°, and water up to 200 ml, and how much alcohol or propylene glycol should be used to prevent the minoxidil from recrystallizing after initial heating and dissolution?
What is the correct preparation method for a testosterone gel originally formulated with oleic acid (10 ml), HPC (3 g), water (30 g), and ethanol 96% (ad 100 g), given that oleic acid is unavailable and an alternative formula using 1 g testosterone, 500 mg Carbopol 940, 65 ml alcohol 96%, 10 g isopropyl myristate (IPM), triethanolamine, and water (ad 100 ml) resulted in ethanol separating and floating on top of the gel after standing overnight, even when IPM was used to replace oleic acid in the original HPC formula?
What is the ideal preparation method for Unguentum Haemo-Nasale MFS—composed of 600 mg Hamamelis liquid extract, 3 g phenazone, 3 g tannin, 6 g water, and Unguentum Simplex up to 30 g—to prevent the formation of a hard mass that cannot be rubbed?
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