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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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How can the formation of fine crystals be avoided in a modified sugar-free cough syrup containing dextromethorphan, prepared according to TMF guidelines but with banana aroma replaced by eucalyptol (0.2 g/l) and the addition of green dye (Viride 7069, 100 mg/l), given that the process involves mixing dextromethorphan with sorbitol, adding citric acid, then adding a solution of sodium saccharin in water, followed by eucalyptol and water for preservation, and finally adding potassium sorbate dissolved in water and the dye, resulting in crystallization at a pH of 4 to 5?
Is it possible to prepare a sodium perchlorate injection for intravenous administration, specifically for a 4-week-old infant requiring a dose of approximately 100 mg for thyroid protection during a radiopharmaceutical examination, and are there known preparation data and stability information for such a formulation?
Is it necessary to store dextromethorphan syrup in a brown bottle to protect it from light, or is the effect of light negligible?
I am observing water separation in the following W/O cream containing a high amount of ZnO: Prednisolone 0.3g, Chloramphenicol 1.2g, Vaseline 10g, Lanolin 10g, ZnO 10g, and Water 10g; how can this be resolved?
What recommendation can be given for a formulation containing 300 mg Promethazine HCl, 1 g Ascorbic acid, 4 g raspberry aroma, and Respacal 0.02% syrup ad 200 ml, given that the physician wants to replace the Respacal syrup with Respacal 20 tablets due to supply issues and rejected the pharmacist's suggestion to use Bricanyl syrup?
For many raw materials, it is stated that they should be kept away from the influence of light; what measures should be taken for processing these materials, such as turning off lights or avoiding transparent capsules?
What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?
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