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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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In a shampoo formulation containing 3 g lactic acid, 6 g salicylic acid, 2% miglyol 812, 60 g sodium lauryl sulfate, 2 million units nystatin, 2 g erythromycin, and water up to 300 cc, what is the function of miglyol, can it be used to solubilize salicylic acid, would it eliminate the need for cetomacrogol, and is it advisable to solubilize nystatin simultaneously with salicylic acid?
What is the shelf life of a vancomycin syrup prepared with syrupus simplex, given that the ampoule's package leaflet specifies a refrigerated shelf life of only 4 days, while the hospital guidelines state 14 days and internet sources provide conflicting information?
How should a prescription for a penetrating ointment containing 10% ketamine, 0.3% clonidine, and 5% diclofenac be handled given that ketamine HCl bulk powder costs €90 for 10g, and can Ketalar ampoules (50mg/ml) be used as a cheaper alternative despite the large volume required to reach a 10% concentration, or is the PLO gel mentioned by KU Leuven available as a finished product in Belgium, and if so, who is the supplier, considering Pentravan cream costs €32.46?
How can L-arginine be properly processed into a syrup for a disabled child who takes 500mg daily for fever spikes, given that capsules are difficult to swallow, a prepared syrup causes gagging, and mixing the capsule contents with grenadine causes an immediate black discoloration, leading to concerns about potential oxidation, safety, and remaining efficacy?
Does the preparation of a minoxidil 5% solution with cetomacrogol 1000 and isopropanol still result in crystallization, and is the use of isopropanol instead of ethanol a possible cause for this?
What formula would you suggest for a stable nasal ointment or cream containing 5% minoxidil without corticosteroids, suitable for a general practitioner to prescribe?
What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?
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