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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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How should I prepare artificial earwax with a composition of 50% yellow vaseline, 5% stearic acid, 5% glyceryl monostearate, 15% monoolein, 15% undecylenic acid, and 10% Cetiol V?
Is a metformin HCl solution consisting of 10 g metformin HCl, 500 mg sodium saccharinate, 25 drops of bromoform aroma, and water up to 100 mL stable, and is it necessary to add potassium bicarbonate, hydrogen chloride, a buffer, or a preservative, given that similar formulations like the American specialty Riomet are referenced on the Qualenica website?
Why does a solution of 0.5% chlorhexidine and 0.64% betamethasone dipropionate in 100 ml isopropyl alcohol result in precipitation when using a 20% chlorhexidine digluconate solution (Pannoc), even without betamethasone, whereas using Hibitane 5% (containing 5% chlorhexidine digluconate, alcohol propoxylate ethoxylate, linalyl acetate, D-gluconolactone, isopropyl alcohol, carmoisine E122, and purified water) for dilution with isopropyl alcohol prevents precipitation despite the resulting pink color?
Why is the following cream breaking, and is the base used (lanae alcoholum unguentum aquosum) incorrect, given the prescription for Amylocaine HCl 3g, hydrocortisone acetate 125 mg, bacitracin 35.5 mg, propylene glycol 1 g, metronidazole 0.25 g, and lanae alcoholum unguentum aquosum up to 30 g, while the original prescription specified ung. eucerin cum aqua 50%?
What is the reason for the failure when preparing aqueous Vitamin A drops of 100,000 IU/g using the method suggested at the IPSA evening, given that the synthetic Vitamin A palmitate oily concentrate has a butter-like consistency and briefly warming the raw material to make it liquid does not help because it solidifies again when mixed with Tween?
Since Lacrytube is no longer available and the client finds Duratears and Vita-Pos eye ointments uncomfortable, can a compounded preparation be made for them based on the composition of Lacrytube, which contains 300.0 mg liquid paraffin, 600.0 mg white vaseline, and 100.0 mg wool fat per gram?
Aluminum chloride 20% in Beeler basis is not stable; can another cream base be used for this, or would a lotion be a better solution?
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