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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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What is the recommended advice for formulating a thick anesthetic cream for minor cosmetic procedures containing 20% benzocaine, 6% lidocaine, and 4% tetracaine, given that attempts using a PEG ointment base with 10% water resulted in a liquid consistency, and subsequent additions of cetylalcohol and reduced water provided some stability but initially led to separation?
What can be done to address the precipitation that occurs when water is added to a propylene glycol solution containing 50 mg of chloramphenicol and 50 mg of hydrocortisone, given that while polymyxin B (100,000 IU) dissolves perfectly in the 5 ml of water, both chloramphenicol and hydrocortisone appear to precipitate out of the 5 mg propylene glycol mixture upon dilution?
What is the ideal method for creating a stable and palatable suspension for the prescription of Elthyrone 0.025 mg and Strumazol 10 mg/5 cc (total volume 200 cc), given that the previously used raw materials are no longer available and the current preparation using specialty medications results in a very large amount of powder?
What is the composition of sugar paste with Isobetadine?
What is the recommended preparation method to prevent the breaking of a cream containing 4% hydroquinone, 4% kojic acid, and 0.05% retinoic acid in a cetomacrogol cream base, and can the stability be improved by using 0.01% butylhydroxytoluene as an antioxidant and replacing the base with buffered cetomacrogol cream (Unguentum emulsificans cum aqua)?
The gel breaks and becomes very liquid when mixing the raw materials; can this gel remain stable with these ingredients, or is another ointment base recommended for a preparation containing 15 g menthol, 15 g camphor, 1.5 g lavender essence, 15 g eucalyptus tincture, 6 g menthol oil 1%, and carbopol gel up to 300 g?
How can the following formula—consisting of 26.4 g almond oil, 10.8 g Cetiol V, 1.5 g stearic acid, 2.55 g cetyl alcohol, 3.3 g Cremophor, 0.45 g boric acid, and aqua conservans up to 200 g—be adjusted to achieve a thicker consistency similar to Mustela toilet milk, given that the current emulsion is very liquid and milky, and would increasing the amount of cetyl alcohol be the best approach or are there better alternatives?
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