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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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How can 10 mg of triamcinolone acetonide be incorporated into a Fluroblastine ampoule, given that Fluroblastine is a solution of vinblastine in an alkaline aqueous solution in which triamcinolone does not dissolve, and considering that the mixture must be sterile for injection to treat scars?
Is it possible to compounded a testosterone gel yourself, given that the preparation is currently obtained from Pharmaproduktion GmbH in Frankfurt and the following formulas are available: a formula from Pharmaproduktion consisting of Testosterone micro 10% (100 mg/g), vitamin F liposomes, ethanol 96%, Audor gel (carbopol 980) NF, sodium hyaluronate, NaOH, panthenol, phenonip, and aqua purif. (to be kept cold); and a formula from Apotheke am Eschenheimer Turm Frankfurt where 20 g of Part A (30 g gel: Carbomer Na, Hydrolite-5, NaOH, aqua) is mixed with 80 g of Part B (90 g gel: 100 g contains 12.5 g testosterone propionate with PC-liposome, cholesterol, Hydrolite-5, ethanol, Carbomer Na, Protriol, and aqua)?
Can you provide a good formula for a penicillin syrup where the active ingredient is phenoxymethylpenicillin potassium?
How can a clear gel be obtained for a formulation containing 5% ibuprofen, 5% methyl salicylate, and 0.5% methyl nicotinate for a 50 g preparation, considering that using a carbomer gel basis and dissolving ibuprofen in a small amount of isopropanol results in a pale white gel, and given that a clear appearance is necessary for ibuprofen's activity while methylcellulose is unsuitable due to incompatibility with methyl salicylate?
What is the cause of the turbidity when 10 ml of Drosera tincture is added to 150 ml of Ventolin syrup, given that mixing Ventolin with pholcodine syrup or Drosera tincture with pholcodine syrup does not cause problems, and can this be resolved for this formula which was originally based on Respacal syrup but must now use Ventolin syrup?
Is it necessary to add an emulsifier to prepare Eucerine cum aqua (50%), and if so, in what quantity, given that previous attempts using Arlacel and Tween 80 were unsuccessful and resulted in the cream separating, and how can this preparation be better approached?
What could be the cause of a strong sulfur odor developing after approximately 1.5 months in a Kaomycin suspension prepared for veterinary use—consisting of neomycin sulfate and pectin dissolved in water, with kaolin suspended in 5% methylcellulose mucilage—given that the suspension was initially stable but no preservatives or other excipients were added?
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