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The compounding helpdesk contains more than 1500 questions and answers on various galenic topics, all provided by Prof. R. Kinget.
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Is there a guideline regarding the use of a tracer dye in the preparation of capsules, for example, when the percentage of active substance in the total mixture is less than or equal to 1%?
What is the best way to prepare a vaseline-cetomacrogol cream consisting of 60 g white vaseline and buffered cetomacrogol cream up to 300 g, considering that simple mixing often yields poor quality and alternative methods involve geometric dilution into molten vaseline followed by ointment milling; specifically, can the vaseline be added directly to the fat phase of a freshly prepared cetomacrogol cream, and if so, is it necessary to compensate by adding more emulsifier or reducing other components of the original fat phase?
Given that Terra Cortril suspension will be unavailable until April, is there a possibility to provide a compounded preparation for this, with a composition per 1 g consisting of 5.7 mg oxytetracycline (as oxytetracycline hydrochloride), 17 mg hydrocortisone acetate, 11,400 U polymyxin B (as polymyxin B sulfate), aluminum tristearate, and liquid paraffin?
What is the best way to prepare a formulation containing 5 g urea, 20 g vaseline, and cetomacrogol cream up to 100 g, considering the options of cold-processing the vaseline—which is difficult due to the high quantity—or starting from the raw materials of the cetomacrogol cream, which would likely require adjusting the formula?
What is a suitable alternative and corresponding dosage for a magistral preparation intended for rinsing a bladder catheter, originally prescribed as 45 g ammonium nitrate, 3% peppermint spirit, and purified water up to 300 g, given that ammonium nitrate is no longer commercially available while ammonium bicarbonate, ammonium acetate, and ammonium sulfate remain accessible?
What is the best preparation method for the following recipe: 1 g prednisolone, 2 g erythromycin, 4 g Arlacel, 46 g white petrolatum, and water up to 100 g, and which ointment base is recommended given that the ointment currently separates and releases water after a few minutes?
Can thymol, which is currently unavailable, be replaced with thyme essential oil in a dog ear cleaner solution composed of 38 g glycerol, 51.5 g propylene glycol, 50 g salicylic acid, 10 g thymol, 2 g camphor, 25 g benzyl benzoate, 250 g Dettol, 1.5 liters of distilled water, and isopropanol up to 5 liters?
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