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Die Rezeptur‑Helpdesk enthält mehr als 1500 Fragen und Antworten zu verschiedenen galenischen Themen, alle bereitgestellt von Prof. R. Kinget.
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How can a good result be obtained for the following preparation: 2% salicylic acid, 5% Liquor carbonis detergens, 1% castor oil, 15% ethanol, and water up to 100%?
Is it still possible to prepare anhydrous glycerin suppositories, given that they apparently can no longer be prepared in the Netherlands for unknown reasons and there is uncertainty about whether the formula (312.2g glycerol and 29.2g sodium stearate for 100 suppositories) contains a certain amount of water, and since sodium stearate is no longer available in Belgium, what is an alternative for it?
How can a stable and uniform syrup be obtained for a preparation containing 10 g codeine syrup, 5 g NaHCO3, 0.05 g chlorophyllinum pulvis 100% (Na-Cu-chlorophylline complex), 5 g spiritus, 0.5 g aetheroli pini, 100 ml aqua conservans, and sirupus simplex ad 200 ml, given that after approximately one week the green pigments flocculate, oil spots appear, and dark green dots of pigment form?
How can a smooth emulsion be prepared for a formulation containing 3g DL-lactic acid, 9g colloidal sulfur, 0.9g prednisolone, 30mg triamcinolone acetonide, 30g paraffin oil, 25.5g stearic acid, 9g Tween 20, 9g coal tar saponine, and water up to 300cc, given that heating the paraffin, stearic acid, Tween, and most of the water results in a crumbly mixture that remains crumbly even after adding extra Tween 20?
Regarding the solution for local nasal anesthesia containing 2g cocaine HCl, 4 drops of 0.1% adrenaline, and aqua ad 20ml intended for preoperative use and subsequent mixing with Fluimicil by a physician, what are the requirements for stability, the addition of preservatives, and light protection, particularly in comparison to the USP formulation containing 4g cocaine HCl, 1g tetracaine HCl, 25ml adrenaline 1/1000, 10mg benzalkonium, 6.4mg disodium EDTA, and 35ml NaCl 0.9% per 100ml water-based solution?
How should a mouthwash containing 1% tetracycline HCl, 1% NaCMC, 0.5% lidocaine, 1.5 g vitamin A, 90 cc syrupus simplex, and peppermint water up to 300 ml be prepared, given that NaCMC is incompatible with tetracycline and lidocaine and must be replaced by methylcellulose?
What are the stability problems of a solution containing 3 grams of Phenobarbital sodium and purified water up to 300 cc?
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