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Die Rezeptur‑Helpdesk enthält mehr als 1500 Fragen und Antworten zu verschiedenen galenischen Themen, alle bereitgestellt von Prof. R. Kinget.
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What is the advice for rectally administering an aliquot from a Valium ampoule using a syringe and a rectal cannula (Codali cnk 1717602), and once transferred to the syringe, how long does the injection fluid remain stable and what are the storage requirements?
What is the best way to prepare a syrup containing 160 mg bromhexine hydrochloride, 130 mg pholcodine, HEC q.s., and raspberry syrup up to 200 ml, specifically regarding how much tartaric acid and water are needed to dissolve the bromhexine hydrochloride, whether the pholcodine can be dissolved in an additional 7 ml of water, and if the addition of HEC is necessary?
What is the most accurate and stable way to prepare a cream consisting of 7.5 mg tretinoin and cremor non ionicus aquosus up to 30 g, specifically regarding whether a trituration in lactose or mannitol can be used, if such a trituration remains stable for a long time, whether an alcohol solution should be avoided due to solubility and volume issues, and if an antioxidant must be added in any case?
What is the cause of the recrystallization of minoxidil, and what are the required amounts of alcohol or propylene glycol to ensure stability in a preparation containing 4 g minoxidil, 60 mg betamethasone valerate, 20 g propylene glycol, 30 g alcohol 60°, and water up to 200 ml, given that the components initially dissolve with heating but precipitate after several hours?
Is there a risk of explosion during preparation (should mercury oxycyanide only be dissolved in water), is the dose of mercury oxycyanide too high, and can potassium nitrate be replaced?
What is a suitable alternative for lead oxide plaster in a fissure ointment formula consisting of 1 g salicylic acid, 2.5 g saponinated coal tar, 12.5 g lead oxide plaster, 12.5 g peanut oil, and yellow petrolatum up to 50 g, given that lead oxide plaster is no longer available?
What is the current status regarding "Cold cream"?
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