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Die Rezeptur‑Helpdesk enthält mehr als 1500 Fragen und Antworten zu verschiedenen galenischen Themen, alle bereitgestellt von Prof. R. Kinget.
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How can a stable emulsion be prepared for a formulation containing 0.1% lidocaine HCl, 0.6% benzocaine, 1% phenol, and 1% menthol in cetomacrogol lotion NF6 up to 250 ml, given that using liquefied phenol currently results in phase separation?
How should suppositories containing 50 mg bismuth subgallate, 50 mg zinc oxide, 50 mg procaine HCl, 2 mg prednisolone, and 5 drops of adrenaline solution be prepared?
What is the cause of the "tough slime" or "clump" formation when preparing a shampoo containing 3 g miconazole nitrate, 20 g tegobetaine L7, 4 g comperlan KD, 100 g Texapon NSO (used instead of Texapon N40), 0.05 g citric acid, and aqua ad 200 g, and does this phenomenon result from the substitution of Texapon N40 with Texapon NSO or a reaction between the miconazole nitrate salt and one of the shampoo base components?
What is the cause of the grey discoloration and firmer consistency observed after three weeks in a formulation containing 0.75% chlorhexidine gluconate and 2% miconazole nitrate in cetomacrogol cream up to 50g, and is there an incompatibility between chlorhexidine and nitrate?
What is the best approach for a magistral preparation containing 10% zinc oxide and 1% hydrocortisone acetate in aqua vivax (AVA), considering that while the TMF recommends this base, there are concerns regarding stability similar to buffered cetomacrogol cream; specifically, is it sufficient to ensure an acidic pH using lactic acid or citric acid, despite potential incompatibilities between citric acid and hydrocortisone acetate, can lactic acid be added to a pre-prepared W/O base to achieve pH 5, or would it be preferable to use an alternative W/O base such as sorbitan cream (cremor sorbatis PMF)?
How can a solution be prepared with 2 g hydrocortisone acetate, 20 g propylene glycol, 100 ml 95% ethanol, and distilled water up to 200 ml, given that the hydrocortisone acetate dissolves in the propylene glycol and ethanol after heating but precipitates again upon the addition of water and cooling; and can this be resolved using excipients or is a different solution required?
How do you prepare a mitomycin 0.02% collyrium without preservatives?
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